Epithalon

Epithalon was developed by the St. Petersburg Institute of Bioregulation and Gerontology as a synthetic alternative to the natural pineal gland extract, Epithalamin. Research indicates that this specific four-amino acid sequence (Ala-Glu-Asp-Gly) is the active component responsible for the pineal gland’s bioregulatory effects.

Scientific studies have demonstrated that Epithalon acts as a telomerase activator. By upregulating the expression of the catalytic subunit of telomerase in somatic cells, it facilitates the elongation of telomeres—the protective caps at the ends of chromosomes that typically shorten with each cell division. Beyond telomere biology, Epithalon is investigated for its role in regulating the circadian rhythm via melatonin synthesis, improving immune function, and exhibiting antioxidant properties in aged animal models.

Product Specifications:

• Sequence: Ala-Glu-Asp-Gly (AEDG)​

• Molecular Formula: C14H22N4O9​

• Molecular Weight: 390.35 g/mol​

• CAS Number: 307297-39-8​

• Purity: ≥99% (HPLC)

• Form: Lyophilized White Powder

Storage & Handling:
Lyophilized Epithalon is stable at room temperature for short periods but should be stored at -20°C for long-term preservation (up to several years). Upon reconstitution with bacteriostatic water, the solution should be kept refrigerated at 4°C. While relatively stable compared to longer peptides, it is recommended to use the reconstituted solution within 2-3 weeks and avoid repeated freeze-thaw cycles.

Disclaimer:
All products listed on this website, including Epithalon, are for laboratory research purposes only. They are not intended for use as drugs, food additives, or cosmetic products. This product is not approved by the FDA for human use and should not be ingested or administered to humans or animals.

FAQ

What is the difference between Epithalon and Epithalamin?
Epithalamin is a natural extract from the pineal gland of calves, containing a complex mixture of peptides. Epithalon is the single, synthetic tetrapeptide (Ala-Glu-Asp-Gly) identified as the active ingredient in that extract. Being synthetic, Epithalon has higher purity and consistency for research purposes.​

How does Epithalon affect telomeres in research?
Telomeres shorten every time a cell divides, eventually leading to cell death (senescence). Research shows that Epithalon induces the production of telomerase, an enzyme that adds DNA sequences back to telomeres, effectively “resetting” the biological clock of the cell in vitro.

Does this peptide influence sleep cycles?
Research suggests that Epithalon can stimulate the pineal gland to normalize the production of melatonin and restore proper circadian rhythms, which are often disrupted in aging models.

Is Epithalon stable?
As a very short peptide (only 4 amino acids), Epithalon is chemically more stable than larger protein-like peptides. However, standard research protocols still require it to be stored lyophilized in a freezer and refrigerated after mixing to maintain maximum potency.​