Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences by combining the sequence of the natural peptide tuftsin (Thr-Lys-Pro-Arg) with a stabilizing tripeptide extension. This modification significantly extends its half-life compared to the rapidly degraded natural tuftsin, allowing for sustained biological activity in experimental models.
Mechanistic studies suggest that Selank acts as a stable regulatory peptide that modulates the activity of GABA-A receptors and influences the metabolism of monoamines (serotonin, dopamine, norepinephrine) in the brain. Unlike typical benzodiazepines, Selank is studied for its ability to reduce anxiety and improve cognitive function under stress without causing sedation, addiction, or withdrawal symptoms in animal models. Additionally, due to its tuftsin origin, it retains immunomodulatory properties, making it a unique subject for neuroimmunology research.
Product Specifications:
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Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
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Molecular Formula: C33H57N11O9
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Molecular Weight: 751.9 g/mol
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CAS Number: 129954-34-3 (often cited as Selank diacetate)
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Purity: ≥99% (HPLC)
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Form: Lyophilized White Powder
Storage & Handling:
Lyophilized Selank is stable at room temperature for short durations (up to 3 weeks) but should be stored desiccated below -20°C for long-term preservation. Upon reconstitution with bacteriostatic water or sterile water, the solution should be stored at 4°C. For extended storage of the solution, aliquoting and freezing at -20°C is recommended to prevent degradation, although fresh preparation is preferred for optimal stability.
Disclaimer:
All products listed on this website, including Selank, are for laboratory research purposes only. They are not intended for use as drugs, food additives, or cosmetic products. This product is not approved by the FDA for human use and should not be ingested or administered to humans or animals.
FAQ
What is the difference between Selank and Semax?
While both are Russian-developed regulatory peptides, they have distinct primary targets. Selank is structurally related to tuftsin and is primarily studied for its anxiolytic (calming) and immunomodulatory effects via GABA and serotonin modulation. Semax is an analogue of ACTH and is researched more for its stimulating, neuroprotective, and cognitive-enhancing effects via dopamine and BDNF upregulation.
Does Selank cause sedation in research models?
One of the key distinguishing features of Selank in preclinical literature is its ability to reduce anxiety-like behaviors without the sedative, muscle-relaxant, or amnesic side effects typically associated with conventional GABA-ergic drugs like benzodiazepines.
Is Selank an immune system modulator?
Yes. Because Selank is a derivative of tuftsin (a natural tetrapeptide produced by the spleen), it retains the ability to modulate the immune response. Research indicates it can influence the expression of cytokines (like IL-6) and support immune function, particularly under conditions of stress.
How is the peptide administered in research?
In laboratory settings, Selank represents a versatile peptide that can be administered via subcutaneous injection or intranasally (as a spray), owing to its relatively small size and stability. However, this product is sold as a lyophilized powder primarily for injectable research preparation.
