Sermorelin

Sermorelin is a synthetic peptide comprising the amino-terminal segment (residues 1–29) of the naturally occurring growth hormone-releasing hormone (GHRH). Research has established that this truncated sequence possesses the essential functional domain required to bind and activate the GHRH receptor on anterior pituitary somatotrophs.

Unlike the administration of exogenous Growth Hormone (HGH), which bypasses natural regulatory loops, Sermorelin is investigated for its ability to stimulate endogenous GH production while maintaining the body’s negative feedback mechanisms (somatostatin inhibition). This property makes it a valuable tool in longevity and metabolic research for exploring how to restore age-related decline in GH levels without inducing supraphysiological side effects often associated with direct HGH application.

Product Specifications:

• Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2

• Molecular Formula: C149H246N44O42S

• Molecular Weight: 3357.9 g/mol

• CAS Number: 86168-78-7

• Purity: ≥99% (HPLC)

• Form: Lyophilized White Powder

Storage & Handling:
Lyophilized Sermorelin should be stored at -20°C for long-term stability. After reconstitution with bacteriostatic water, the peptide is sensitive to heat and enzymatic degradation; it must be kept refrigerated at 4°C and used typically within 30 days. Research protocols emphasize avoiding repeated freeze-thaw cycles to preserve molecular integrity.

Disclaimer:
All products listed on this website, including Sermorelin, are for laboratory research purposes only. They are not intended for use as drugs, food additives, or cosmetic products. This product is not approved by the FDA for human use and should not be ingested or administered to humans or animals.

FAQ

What is the difference between Sermorelin and HGH?
Sermorelin is a secretagogue that stimulates the pituitary gland to produce its own Growth Hormone (GH), thereby preserving natural pulsatile release patterns. HGH (recombinant human growth hormone) is the exogenous form of the hormone itself, which replaces natural production and can suppress the body’s own synthesis.

Why is it called GHRH (1-29)?
Native GHRH consists of 44 amino acids. Research discovered that the biological activity resides entirely in the first 29 amino acids. Therefore, Sermorelin (1-29) is a truncated analog that is structurally smaller but functionally equivalent in receptor binding.

Is Sermorelin the same as CJC-1295?
No. While both are GHRH analogs, CJC-1295 is often modified (e.g., with DAC or specific amino acid substitutions) to drastically extend its half-life. Sermorelin has a very short half-life (approx. 10-20 minutes), mimicking the natural short bursts of GHRH release from the hypothalamus.

How do I store the peptide after mixing?
Once reconstituted, Sermorelin is quite fragile. It must be stored in the refrigerator (2-8°C) and protected from light. Do not freeze it again after mixing, as this can damage the peptide structure.