MOTS-c

MOTS-c represents a novel class of mitochondrial-derived peptides (MDPs) that facilitate communication between the mitochondria and the nucleus to regulate cellular metabolism under stress. Unlike nuclear-encoded peptides, MOTS-c is encoded by the mitochondrial 12S rRNA region.

Research studies have demonstrated that MOTS-c targets the folate cycle and activates AMP-activated protein kinase (AMPK), a master regulator of energy metabolism. This activation mimics the physiological effects of exercise, leading to improved insulin sensitivity, reduced diet-induced obesity, and enhanced physical performance in animal models. It is extensively studied for its potential role in age-related metabolic decline and longevity.

Product Specifications:

• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg​

• Molecular Formula: C101H152N28O22S2​

• Molecular Weight: 2174.6 g/mol​

• CAS Number: 1627580-64-6​

• Purity: ≥99% (HPLC)

• Form: Lyophilized White Powder

Storage & Handling:
Lyophilized MOTS-c should be stored at -20°C. Upon reconstitution, this peptide requires careful handling; while some sources suggest it is stable for up to 30 days at 4°C, others recommend using it rapidly due to potential aggregation or oxidation risks associated with methionine residues. Avoid vortexing; use gentle swirling to dissolve.

Disclaimer:
All products listed on this website, including MOTS-c, are for laboratory research purposes only. They are not intended for use as drugs, food additives, or cosmetic products. This product is not approved by the FDA for human use and should not be ingested or administered to humans or animals.

FAQ

What makes MOTS-c different from other peptides?
MOTS-c is unique because it is encoded by mitochondrial DNA (mtDNA), not nuclear DNA. It acts as a retrograde signal, transmitting information about mitochondrial metabolic status to the nucleus to regulate gene expression involved in stress resistance and metabolism.

Why is it called an “exercise mimetic”?
Research shows that MOTS-c administration can activate skeletal muscle AMPK and increase glucose uptake without physical exertion, replicating the cellular signaling pathways typically triggered by endurance exercise.​

Is MOTS-c stable in solution?
Recent mass spectrometry studies suggest reasonable stability at 4°C for up to 30 days, contradicting earlier beliefs of extremely rapid degradation. However, due to its structure, it is still best practice in research to store it cold and minimize freeze-thaw cycles.

Does this peptide act on the folate cycle?
Yes, MOTS-c has been shown to inhibit the folate cycle at the level of 5AICAR, leading to an increase in cellular AICAR levels, which subsequently activates AMPK. This is a distinct mechanism compared to other metabolic peptides like Semaglutide.​