Melanotan 2 was originally developed to study the stimulation of melanin production without the need for ultraviolet (UV) radiation exposure. Research indicates that unlike its predecessor Melanotan I (Afamelanotide), MT-2 acts as a non-selective agonist with high affinity for MC1, MC3, MC4, and MC5 receptors.

This broad receptor binding profile allows researchers to explore multiple physiological pathways simultaneously: the activation of MC1R leads to increased melanogenesis (tanning), while binding to MC3R and MC4R in the central nervous system is linked to effects on sexual arousal and metabolic regulation (reduced food intake). Its cyclic lactam structure protects it from rapid enzymatic degradation, offering significantly higher potency and stability in experimental models compared to linear α-MSH.

Product Specifications:

• Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

• Molecular Formula: C50H69N15O9

• Molecular Weight: 1024.2 g/mol

• CAS Number: 121062-08-6

• Purity: ≥99% (HPLC)

• Form: Lyophilized White Powder

Storage & Handling:
Lyophilized Melanotan 2 is stable at room temperature for short durations (up to 3 weeks) but should be stored desiccated below -18°C for long-term stability (1-2+ years). Upon reconstitution with bacteriostatic water, the solution must be stored at 4°C (refrigerated) and used within 30-60 days to prevent degradation and loss of potency.

Disclaimer:
All products listed on this website, including Melanotan 2, are for laboratory research purposes only. They are not intended for use as drugs, food additives, or cosmetic products. This product is not approved by the FDA for human use and should not be ingested or administered to humans or animals.

FAQ

What is the difference between Melanotan 2 and PT-141?
Melanotan 2 is the parent peptide from which PT-141 (Bremelanotide) was derived. While MT-2 activates the MC1 receptor (causing tanning) in addition to CNS receptors, PT-141 is a metabolite of MT-2 that lacks the C-terminal amide group responsible for strong MC1R binding. This makes PT-141 more specific for sexual function research without the tanning side effect.

Why is it called a “non-selective” agonist?
“Non-selective” means that Melanotan 2 binds to multiple types of melanocortin receptors (MC1, MC3, MC4, MC5) rather than just one. This is why research on MT-2 observes a wide range of effects, including pigmentation, appetite suppression, and libido enhancement, rather than a single isolated outcome.

Does Melanotan 2 require UV exposure in research?
While MT-2 stimulates melanin production independently, research suggests that the presence of UV light can potentiate the melanogenic process. However, the peptide itself is capable of upregulating the enzymatic machinery (tyrosinase) for pigmentation without direct UV radiation.

How long does the reconstituted peptide last?
Once mixed with bacteriostatic water, Melanotan 2 is reasonably stable if kept refrigerated (2-8°C). Standard laboratory protocols recommend using the reconstituted solution within 4-8 weeks to ensure data consistency, as peptides in solution slowly degrade over time.