TB-500
$100.00
TB-500 is a synthetic peptide analogue of Thymosin Beta-4 (Tβ4), a naturally occurring protein that plays a vital role in cell structure and tissue repair.
In research models, TB-500 is studied for its ability to regulate actin polymerization, a fundamental process for cell migration, angiogenesis, and wound healing.
Note: This product is intended for research use only and is not for human consumption.
TB-500 contains a specific active fraction of the parent protein Thymosin Beta-4, known as the actin-binding domain (sequence: Ac-Ser-Asp-Lys-Pro-D-Phe-His-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu). Research indicates that this specific sequence is responsible for the peptide’s ability to sequester monomeric actin (G-actin), which is critical for maintaining the cellular cytoskeletal reservoir necessary for cell motility and rapid tissue remodeling.
Unlike the full-length Thymosin Beta-4 protein (43 amino acids), TB-500’s lower molecular weight allows for greater tissue penetration and ease of handling in laboratory settings. Scientific studies primarily focus on its potential to promote endothelial cell migration, reduce inflammation, and accelerate the repair of damaged skeletal muscle and connective tissues in various injury models.
Product Specifications:
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Sequence: Ac-Ser-Asp-Lys-Pro-D-Phe-His-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu (Note: Often simplified in literature to LKKTETQ, but research products vary; verify if it’s the full Tβ4 or the fragment. Most “TB-500” sold is the synthetic Tβ4 analog).
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Molecular Formula: C212H350N56O78S (for full Tβ4) or C38H68N10O14 (for fragment) – Standard “TB-500” usually refers to the synthetic Tβ4 sequence in research markets.
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Molecular Weight: ~4963 g/mol (if full Tβ4)
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CAS Number: 77591-33-4
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Purity: ≥99% (HPLC)
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Form: Lyophilized White Powder
Storage & Handling:
Lyophilized TB-500 is stable at room temperature for short periods but should be stored at -20°C for long-term preservation. Upon reconstitution with bacteriostatic water, the peptide should be kept at 4°C and used within 8 days to 2 weeks to ensure maximum viability, as it degrades faster than some other peptides in solution.
Disclaimer:
All products listed on this website, including TB-500, are for laboratory research purposes only. They are not intended for use as drugs, food additives, or cosmetic products. This product is not approved by the FDA for human use and should not be ingested or administered to humans or animals.
FAQ
What is the relationship between TB-500 and Thymosin Beta-4?
Thymosin Beta-4 is a naturally occurring protein found in high concentrations in platelets and wound fluid. TB-500 is a synthetic version of this protein (or a specific active fragment of it) designed for research purposes to mimic the natural regenerative properties of Tβ4.
How does TB-500 work in cell cultures?
The peptide functions by binding to actin, a cellular building block. This interaction promotes “actin sequestration,” keeping actin available for the rapid assembly of new filaments. This process is essential for cells to move (migrate) to sites of injury and repair tissue.
Is TB-500 systemic or local in research applications?
Research suggests that TB-500 has systemic effects, meaning it can circulate throughout the body to reach sites of injury, unlike some growth factors that only act locally. Its low molecular weight facilitates this biodistribution in animal models.
Does TB-500 promote muscle growth?
While often associated with muscle recovery, TB-500’s primary mechanism in research is tissue repair and regeneration (healing damaged fibers) rather than direct hypertrophy (growth of new muscle tissue) like anabolic agents. It is studied for its ability to reduce scar tissue formation and improve muscle fiber organization after injury.
Related Products
BPC-157 5mg, TB-500 (Thymosin Beta-4) 5 mg , GHK-Cu 20 mg
(Total Glow Blend)
The BPC-157, TB-500 (Thymosin Beta-4), and GHK-Cu mix is a mix of three different peptides, measured at 5 mg of BPC-157, 5 mg of TB-500, and 20 mg of GHK-Cu, for a total of 30 mg.
Researchers have been interested in BPC-157, a peptide initially isolated from gastric proteins, because of its ability to promote the growth of blood vessels and healing of injured tissue through a range of cellular mechanisms.
TB-500, a naturally occurring fragment of a larger protein, is typically studied for its ability to migrate cells into injured areas. It encourages the formation of new blood vessels, and reduces inflammation, especially in muscle and connective tissue.
The third ingredient, GHK-Cu, is a low molecular weight copper-binding peptide that has been linked in studies to wound healing, collagen synthesis, and even hair growth stimulation.
Together, these three compounds appear to have an effect on the same biological processes, but with a broader effect than any of them would have in isolation.
For example, TB-500 and BPC-157 both cause the growth of new vessels, while GHK-Cu adds another layer of support by activating the growth of the cells that line blood vessels.
On the structural repair side of tissues, TB-500 enables cell migration by promoting actin activity, while GHK-Cu and BPC-157 both influence fibroblasts and collagen to offer support for stronger connective tissue.
A second point of overlap is in reducing inflammation and oxidative stress, and it may be here that researchers are hopeful for these peptides in longer-term recovery studies.
As a result of these synergistic and shared activities, the blend is being investigated for use in everything ranging from musculoskeletal trauma to wound healing and post-surgical recovery.
The BPC157, TB500, KPV, and GHK-Cu Quad Blend is a premium peptide formulation developed for advanced research into healing, regeneration, and anti-aging. This unique combination brings together four peptides that complement each other through distinct biological pathways. BPC157 has been widely studied for its ability to promote tissue repair, improve circulation, and support the stomach and intestinal lining. TB500, the complete Thymosin Beta-4 peptide, plays a vital role in cellular movement and recovery, helping researchers explore mechanisms of wound and muscle regeneration. KPV, a naturally occurring tripeptide, is valued for its anti-inflammatory and antimicrobial activity, helping to regulate immune response and reduce tissue stress. GHK-Cu, a copper-binding peptide, is known to stimulate collagen synthesis and rejuvenate skin and hair cells, promoting overall cellular renewal.
When combined, these four compounds may act synergistically to support studies on recovery and long-term cellular health. The blend is produced in a GMP-certified facility, tested for ≥99% purity, and provided in lyophilized powder form to ensure stability and reliability for laboratory use. Designed strictly for research purposes, this blend offers scientists a powerful tool to study natural healing and regenerative processes.
Body protection compound 157, or BPC for short, is a 15 amino acid segment of a specific body protection compound fragment.
Research showed that BPC-157 presents itself with potent cytoprotective properties, protecting cells from gastric mucosal damage. Though this exact mechanism is not yet fully known, researchers believe it has to do with the brain-gut axis which enables the communication between central nervous and endocrine systems.
TB-500 is a synthetic variation of the naturally occurring Thymosin-beta-4, and is built up of 43 amino acids. This peptide plays an important role in polymerization regulation, cell proliferation, migration and differentiation.
Putting these two peptides in a blend together gives a powerful cell protection effect, as well as improved recovery and differentiation on a cellular level.
References:
Ipamorelin is a pentapeptide and a synthetic ghrelin mimetic (acting as a ghrelin agonist) with high growth hormone (GH) releasing potency. Since it mimics ghrelin and binds to its receptors (GH secretagogues receptors) in the brain, it stimulates the release of GH in the pituitary gland; which leads to an increase in plasma GH levels, but also increased levels in GA tract, lungs, heart, liver, kidney and pancreas.
What differentiates Ipamorelin from other growth hormone releasing peptides is that it stimulates GH in a way that’s most similar to that of growth hormone-releasing hormone.
References:
- Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):552-61. doi: 10.1530/eje.0.1390552. PMID: 9849822.
- Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J, Pastuszak AW, Lipshultz LI. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol. 2020 Mar;9(Suppl 2):S149-S159. doi: 10.21037/tau.2019.11.30. PMID: 32257855; PMCID: PMC7108996.
CJC-1295 with DAC is a synthetic peptide, analog of the growth hormone-releasing hormone. Though CJC-1295 without DAC has the same effect and stimulates the production and secretion of growth hormone, the addition of Drug Affinity Complex (DAC) is what increases its half-life allowing it to act longer and more potently.
Research in animals also suggests that CJC-1295 with DAC stimulates insulin-like growth factor 1 (IGF-1) and plays a part in a number of physiological processes.
References:
- https://pubmed.ncbi.nlm.nih.gov/16352683/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC2787983/
- https://academic.oup.com/jcem/article-abstract/91/3/799/2843281?redirectedFrom=fulltext
- https://www.researchgate.net/publication/7416716_Prolonged_Stimulation_of_Growth_Hormone_GH_and_Insulin-Like_Growth_Factor_I_Secretion_by_CJC-1295_a_Long-Acting_Analog_of_GH-Releasing_Hormone_in_Healthy_Adults
