Kisspeptin-10 represents the minimal amino acid sequence required to activate the G-protein coupled receptor GPR54 (also known as the Kiss1 receptor) with full intrinsic efficacy. Scientific literature defines the Kisspeptin system as the “master regulator” of puberty and reproduction, acting upstream of the pituitary gland.
Research studies demonstrate that administration of Kisspeptin-10 stimulates the hypothalamus to release GnRH, which in turn triggers the secretion of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) from the pituitary. Unlike exogenous hormones (like HCG or TRT) which can suppress natural endocrine feedback loops, Kisspeptin-10 is investigated for its potential to stimulate the body’s intrinsic hormonal production (endogenous testosterone and gonadotropins) while preserving the physiological pulsatility of the HPG axis.
Product Specifications:
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Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
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Molecular Formula: C63H83N17O14
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Molecular Weight: 1302.4 g/mol
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CAS Number: 374675-21-5
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Purity: ≥99% (HPLC)
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Form: Lyophilized White Powder
Storage & Handling:
Lyophilized Kisspeptin-10 is stable at room temperature for short periods but should be stored at -20°C for long-term preservation to prevent degradation. Upon reconstitution with bacteriostatic water, the solution must be kept refrigerated at 4°C and is generally stable for approximately 3-4 weeks. Avoid repeated freeze-thaw cycles.
Disclaimer:
All products listed on this website, including Kisspeptin-10, are for laboratory research purposes only. They are not intended for use as drugs, food additives, or cosmetic products. This product is not approved by the FDA for human use and should not be ingested or administered to humans or animals.
FAQ
How does Kisspeptin-10 differ from HCG in research models?
HCG (Human Chorionic Gonadotropin) mimics LH directly at the testicular level, bypassing the brain. Kisspeptin-10 acts “upstream” on the hypothalamus, stimulating the natural release of GnRH, which then causes the pituitary to release both LH and FSH. This preserves the natural feedback loops of the HPG axis in experimental models.
Is Kisspeptin-10 the same as Kisspeptin-54?
Kisspeptin-10 is a shorter fragment (10 amino acids) of the full-length Kisspeptin-54 protein. Research indicates that the 10-amino acid fragment retains full biological activity and receptor affinity, making it a more cost-effective and common choice for laboratory studies, although it has a shorter half-life.
What is the “pulsatile” release mentioned in literature?
Endogenous hormones are naturally released in pulses rather than a constant stream. Research shows that Kisspeptin-10 can stimulate LH in a pulsatile manner, which is crucial for maintaining receptor sensitivity and preventing desensitization (tachyphylaxis) often seen with continuous stimulation.
Does this peptide require reconstitution?
Yes, Kisspeptin-10 is supplied as a lyophilized powder. It must be reconstituted with a sterile solvent (typically Bacteriostatic Water) before it can be used in any liquid-based research applications.
